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Determinants and unstable cores in sequential distributive phosphorylation

Michael Mislan

Palomar Registrypalomar/PALOMAR-2026-09-30-000008Sep 30, 2026math.DSscore 0

Vassena and Stadler (arXiv:2308.11486v3, Supplementary Example D) conjectured that sequential distributive phosphorylation cycles have only unstable-positive cores and that every invertible child-selection matrix has determinant of absolute value one. The determinant assertion is proved, and the restriction to unstable-positive cores is disproved. In the n-site cycle, every child-selection matrix has determinant 0, 1 or -1. For every n >= 3, a six-species child-selection matrix is minimally Hurwitz-unstable and has determinant 1, giving an unstable-negative core. For every n >= 2, there is…

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