Attracting oscillations in sequential distributive phosphorylation
Vassena (arXiv:2608.27081v2, Section 8) left open whether sequential distributive phosphorylation cycles with three or more sites admit Hopf bifurcation under mass-action kinetics. For every n >= 3, a componentwise-affine family of positive rate constants is constructed for the n-site cycle with one kinase and one phosphatase and a fixed positive equilibrium. A family of strictly positive, nonconstant periodic orbits bifurcates from this equilibrium, with amplitudes tending to zero and periods tending to a finite positive limit. Each orbit is orbitally asymptotically stable within its…
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